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retinoin Tretin 0.025% Cream is a vitamin A derivative that helps to treat acne, smooth rough skin, and reduce fine wrinkles. It works by unclogging the pores, removing dead skin cells, and reducing inflammation. It also stimulates the production of new collagen, which improves the elasticity and texture of the skin. Apply once daily at bedtime, after washing and drying the affected area. Avoid contact with the eyes, mouth, nose, and mucous membranes. Use a sunscreen and wear protective clothing when exposed to sunlight. Do not use if you are allergic, pregnant, or breastfeeding. Consult your doctor before using this medication.